Active galactic nuclei (AGN) play a crucial role in galaxy evolution through a range of feedback processes between the central supermassive black-hole and its surroundings. We will discuss the latest results in observation- and simulation-driven studies, covering both multi-wavelength and multi-messenger astronomy over a wide range of spatial scales and timescales. In particular, we will showcase work that uses southern-hemisphere telescopes such as MeerKAT, SALT, H.E.S.S., ALMA, and the VLT, in addition to exciting, new observations from JWST, EHT, and the Vera C. Rubin Observatory. Furthermore, we will incorporate a discussion on equity, diversity, and inclusion (EDI) in Astronomy — which is pivotal for the whole community — because researchers may not commonly set aside time to participate in EDI talks or see the relevance of EDI initiatives. This symposium (in Cape Town, South Africa) is an excellent 5-year follow-up to the first IAU Symposium to be held in Ethiopia in over 100 years (“Nuclear activity in galaxies across cosmic time”), and so will continue to establish and develop international collaborations across and beyond the African continent. For this to be successful, we need you and your active engagement!